When it comes to eliminating wrinkles, lines and deep folds, there are two main options to choose from: fillers and denervating agents, both which work differently. Fillers (like Restylane, Perlane and Juvéderm) contain hyaluronic acid to plump up wrinkles from the inside out, giving instant results. Denervating agents (such as Botox and Dysport) temporarily inhibit the muscle contractions that cause wrinkles to form while also preventing new ones from developing.